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ea0056gp10 | Acromegaly | ECE2018

Human growth hormone (GH) isoforms during oral glucose tolerance test in patients with acromegaly and in healthy subjects

Ulmer Esther , Schilbach Katharina , Haenelt Michael , Nicolay Shiva Sophia , Schwerdt Laura , Schweizer Junia Ribeiro de Oliveira Longo , Bartel Christopher , Schopohl Jochen , Strasburger Christian , Wu Zida , Bidlingmaier Martin

GH consists of various molecular isoforms. Most abundant is 22 kDa-GH (8090% of total GH), followed by 20 kDa-GH (515% of total GH). The biological significance of 20 kDa-GH remains unclear, but its effects appear comparable to those of 22 kDa-GH. Acromegaly is characterized by chronic GH excess. Data on GH isoforms in acromegaly are scarce, but an increased 20 kDa-/22 kDa-GH-ratio (20k-ratio) has been described. Our aims were to compare the 20k-ratio in a larger c...

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Endocrine Abstracts

Human growth hormone (GH) isoforms during oral glucose tolerance test in patients with acromegaly and in healthy subjects

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